右美托咪定
医学
谵妄
麻醉
安慰剂
心脏外科
生理盐水
入射(几何)
随机对照试验
外科
镇静
重症监护医学
物理
替代医学
病理
光学
作者
Hongxing Wang,Yuan Jia,Congya Zhang,L. Zhang,Yu-Xian Li,Jian Ding,Xinhai Wu,Zheng Zhang,Jingsheng Wang,Yuyan Wang,Fuxia Yan,Su Yuan,Daniel I. Sessler
出处
期刊:Anaesthesia
[Wiley]
日期:2023-02-16
卷期号:78 (5): 571-576
被引量:9
摘要
Summary Dexmedetomidine might reduce delirium after cardiac surgery. We allocated 326 participants to an infusion of dexmedetomidine at a rate of 0.6 μg kg −1 for 10 min and then at 0.4 μg.kg −1 .h −1 until the end of surgery; 326 control participants received comparable volumes of saline. We detected delirium in 98/652 (15%) participants during the first seven postoperative days: 47/326 after dexmedetomidine vs. 51/326 after placebo, p = 0.62, adjusted relative risk (95%CI) 0.86 (0.56–1.33), p = 0.51. Postoperative renal impairment (Kidney Disease Improving Global Outcomes stages 1, 2 and 3) was detected in 46, 9 and 2 participants after dexmedetomidine and 25, 7 and 4 control participants, p = 0.040. Intra‐operative dexmedetomidine infusion did not reduce the incidence of delirium after cardiac valve surgery but might impair renal function.
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