The lectin from Schinus terebinthifolia leaf (SteLL) reduces immobility of mice on the tail suspension test dependent on the monoaminergic and nitric oxide signaling

单胺类 尾部悬挂试验 药理学 一氧化氮 行为绝望测验 血清素 内科学 抑郁症动物模型 抗焦虑药 抗抑郁药 医学 内分泌学 受体 海马体
作者
Bárbara Raíssa Ferreira de Lima,Leydianne Leite de Siqueira Patriota,Amanda de Oliveira Marinho,Jainaldo Alves da Costa,Thiago Henrique Napoleão,Michelle Melgarejo da Rosa,Patrícia Maria Guedes Paiva
出处
期刊:Neuroscience Letters [Elsevier]
卷期号:801: 137092-137092 被引量:6
标识
DOI:10.1016/j.neulet.2023.137092
摘要

Depression underlies a common psychiatric disorder that has been rising in the diagnosis of long-term disabilities worldwide. Natural products have been studied as an antidepressant and anxiolytic agents aiming to make available new options for the daily basis treatment of those psychological disorders. SteLL is a lectin extracted from Schinus terebinthifolia leaf that has been revealed as an antimicrobial, immunomodulatory, antitumor, and antinociceptive agent. Nonetheless, the efficacy of SteLL in the treatment of depression has not yet been explored. In view of this, the aim of this study was to investigate the effect of SteLL in an acute protocol for symptoms of depression using the tail suspension test (TST) to assess despair. Administration of SteLL (1, 2 e 4 mg/kg) significantly diminished the immobility time of animals in the TST and this anti-immobility action was dependent on the carbohydrate-recognizing domain (CRD) since the prior incubation with casein (an inhibitor of SteLL carbohydrate-binding property) blocked the effect. SteLL effect was also reversed by pre-treatment with pharmacological antagonists of α2-adrenoceptor, 5-HT2A/2C serotonin receptor, and D1 dopamine receptor as well as by a selective inhibitor of iNOS (aminoguanidine). l-arginine, a precursor of NO, potentiated SteLL anti-immobility effect. In a subacute evaluation, the anti-immobility effect of SteLL persisted after seven days of treatment. Our findings suggest a role of SteLL in the modulation of depression mostly through monoaminergic and nitric oxide signaling.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
隐形曼青应助tttqqq采纳,获得10
刚刚
坦率完成签到,获得积分10
2秒前
布丁发布了新的文献求助10
2秒前
cky完成签到,获得积分20
2秒前
fangying789发布了新的文献求助10
3秒前
Tina完成签到,获得积分10
4秒前
XiaoDai完成签到,获得积分10
4秒前
9秒前
10秒前
12秒前
13秒前
EchoJY应助renxuda采纳,获得10
14秒前
ddddddd完成签到 ,获得积分10
15秒前
whh发布了新的文献求助10
17秒前
17秒前
Cyber_relic完成签到,获得积分10
20秒前
劲秉应助whh采纳,获得30
24秒前
NexusExplorer应助whh采纳,获得10
24秒前
小贾完成签到,获得积分10
25秒前
kc135完成签到,获得积分10
26秒前
打工仔完成签到 ,获得积分10
27秒前
30秒前
一心向雨完成签到,获得积分20
34秒前
35秒前
35秒前
明理芷云完成签到,获得积分10
37秒前
英俊的铭应助ffffffflzx666采纳,获得10
44秒前
都是发布了新的文献求助10
44秒前
歪歪扣叉发布了新的文献求助10
44秒前
希望天下0贩的0应助bread采纳,获得10
45秒前
46秒前
鳕鹅完成签到 ,获得积分10
48秒前
whh发布了新的文献求助10
49秒前
50秒前
打打应助都是采纳,获得10
52秒前
小黑子完成签到,获得积分10
52秒前
55秒前
56秒前
58秒前
zxt12305313完成签到 ,获得积分10
59秒前
高分求助中
Earth System Geophysics 1000
Co-opetition under Endogenous Bargaining Power 666
Medicina di laboratorio. Logica e patologia clinica 600
Handbook of Marine Craft Hydrodynamics and Motion Control, 2nd Edition 500
Sarcolestes leedsi Lydekker, an ankylosaurian dinosaur from the Middle Jurassic of England 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
Language injustice and social equity in EMI policies in China 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3212348
求助须知:如何正确求助?哪些是违规求助? 2861200
关于积分的说明 8127627
捐赠科研通 2527168
什么是DOI,文献DOI怎么找? 1360782
科研通“疑难数据库(出版商)”最低求助积分说明 643322
邀请新用户注册赠送积分活动 615664