还原胺化
铱
胺气处理
组合化学
烷基化
胺化
化学
同种类的
小学(天文学)
催化作用
功能群
均相催化
有机化学
数学
组合数学
物理
聚合物
天文
作者
Jing Wang,Wenji Wang,Xiongyu Yang,Jingwen Li,Hefei Huang,Mingxin Chang
标识
DOI:10.1007/s11426-022-1494-7
摘要
Direct reductive amination (DRA) is one of the most efficient methods for amine synthesis. Herein we report a practical homogeneous DRA procedure utilizing iridium catalysis. Applying simple, readily available and inexpensive PPh3 and alike ligands along with iridium at a low loading, aldehydes and ketones reductively coupled with primary and secondary amines to efficiently form structurally and functionally diverse amine products, including a set of drugs and compounds from late-stage manipulation. The reaction conditions were exceptionally mild and additive-free, in which oxygen, moisture, polar protic groups and multiple other functional groups were tolerated. For targeted products, this methodology is especially versatile for offering multiple possible synthetic options. The 10 gram-scale synthesis further demonstrated the potential and promise of this procedure in practical amine synthesis. DFT studies reveal an “outer-sphere” H-addition pathway, in which π−π interactions and H-bonding play important roles.
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