氧甾醇
植物脂质转运蛋白
细胞生物学
生物
细胞器
功能(生物学)
脂滴
生物化学
胆固醇
基因
作者
Yani Lin,Liyuan Ran,Ximing Du,Hongyuan Yang,Yingjie Wu
标识
DOI:10.1016/j.bbalip.2023.159365
摘要
Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases.
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