P-185 Global and regional trends in the incidence and mortality of Colorectal Cancer (CRC): Analysis of data from the GLOBOCAN database and SEER database

Colorectal cancers (CRC) are one of the most commonly diagnosed malignancies after breast and lung. The incidence and mortality varies geographically, thus warranting different control strategies aimed at curbing the prevalence of colon cancer. This retrospective study highlights the current burden of CRC in the United States vs. the countries with the highest rates of colorectal cancer and the highest number of deaths from colorectal cancer in 2020. For the data on burden of CRC in the most affected countries, Age-Standardized rates (ASR) in 2020 were obtained from the GLOBOCAN database. ASR summarizes the disease rate for the population for a standard age structure, which represents influence on the risk of dying from cancer, pertaining to age. The incidence-to-mortality ratio (IMR) was also estimated from ASR. Further stratified data of the occurrences and demographics in the United States from Surveillence, Epidemiology, and End Results (SEER). 1.9 million new cases and 930 000 deaths were attributed to CRC in 2020 worldwide. European countries were overall more affected with Hungary having the highest incidence at 45.3 per 100,000 population. South-Central Asian countries had the lowest incidence at 5.5 per 100,000. The incidence rate in the US was at 25.6 per 100,000. The highest mortality rate was in Slovakia at 29.6 per 100,000 population, lowest in African countries and the US mortality rate was at 8 per 100,000, in 2020. In the US, as per the trends studied between 2000 to 2019, there were a total of 603,994 cases reported. The incidence rate has been steadily declining. It was at 45.11 in 2000, which reduced in 2019, to 30.05 per 100,000 population. The trends continued to remain higher in males as compared to females, with males (35.66/100,000) persistently averaging more than the average incidence for the general popualtion. The incidence was consistently reported to be higher in black population more than whites, asians, pacific islanders, alaskan natives and hispanics. This study was aimed at identifying the importance of the geographical prediliction of CRC, suggesting environmental, social and genetic factors play a huge role in occurrence and progression of CRC to mortality. Colorectal cancer screening is a part of preventive sceening as per national guidelines, reflected in the declining incidence rates in the United States. With incremental trends in certain countries, there is a pressing need to adopt adequate surveillance measures to control the incidence.