Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis

医学 荟萃分析 内科学 系统回顾 随机对照试验 胃肠病学 子群分析 梅德林 政治学 法学
作者
Dongliang Liu,Xilu Wang,Hang Zhang
出处
期刊:Phytomedicine [Elsevier BV]
卷期号:118: 154948-154948 被引量:4
标识
DOI:10.1016/j.phymed.2023.154948
摘要

Allergic rhinitis (AR) is a non-infective chronic inflammatory disease of nasal mucosa.To evaluate the efficacy and safety of gastrointestinal microbiome supplementation (GMS) for patients with allergic rhinitis (AR), concerning improvement on symptoms and signs, laboratory outcomes, quality of life, and medication scores.Five English databases were searched up to Dec 12th, 2022. Probiotics, prebiotics, and synbiotics were main therapies or adjuvants in experimental groups. Systematic reviews and meta-analyses were conducted based on the Cochrane systematic review method by using RevMan 5.4 Software, with meta-influence analyses, subgroup-analyses, meta-regression, and publication bias performed for exploration of heterogeneity by Stata V.14. Trial sequential analyses were performed by TSA 0.9, and quality of the results was accessed through the GRADE-pro GDT.Finally, extracted from 53 articles, 65 RCTs involving 3,634 participants with sound worldwide representativeness were included. Primary results showed better improvement in GMS groups on TNSS (WMD=1.05, P for WMD=0.004, 95%CI:0.34 to 1.76), overall nasal condition (WMD=1.25, P for WMD<0.001, 95%CI:0.90 to 1.61), overall quality of life (WMD=6.16, P for WMD<0.001, 95%CI:4.92 to 7.40) and medication score (WMD=0.42, P for WMD=0.42, 95%CI:-0.06 to 0.90).However, GMS groups were inferior than the controls concerning reduction on serum total IgE (WMD=-1.81) and ratios of serum Th1/Th2 (WMD=-1.06). Meta-regressions suggested significant (p<0.05) variations of the effects in some comparisons. In addition, results of sub-group analyses firstly revealed potential influence between final results and the variables above. Instantly after intervention, the GRADE levels of evidence were sound, including "High ⨁⨁⨁⨁" in 10, "Moderate ⨁⨁⨁◯" in 33, and "Low ⨁⨁◯◯" in nine comparisons. However, overall certainties decreased obviously during follow-ups.Overall, our pooled results firstly revealed that GMS yielded acceptable benefits for patients with AR compared with controls with sound certainties, after balancing the benefits and harms.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
包李完成签到,获得积分10
1秒前
科研小虫完成签到,获得积分10
4秒前
nianxunxi完成签到,获得积分10
5秒前
CipherSage应助一颗椰子糖耶采纳,获得10
5秒前
6秒前
慕青应助叶子采纳,获得10
7秒前
8秒前
无花果应助漂亮白枫采纳,获得10
10秒前
dormraider完成签到,获得积分10
10秒前
11秒前
12秒前
14秒前
ppwl完成签到,获得积分10
15秒前
15秒前
万能图书馆应助bbh采纳,获得10
16秒前
星辰大海应助bbh采纳,获得10
16秒前
Lucas应助bbh采纳,获得10
16秒前
希望天下0贩的0应助bbh采纳,获得10
16秒前
充电宝应助bbh采纳,获得10
16秒前
所所应助bbh采纳,获得10
16秒前
完美世界应助bbh采纳,获得10
16秒前
SciGPT应助bbh采纳,获得10
16秒前
酷波er应助bbh采纳,获得10
16秒前
爱宝乐宝福宝应助bbh采纳,获得10
16秒前
18秒前
19秒前
好消息发布了新的文献求助20
20秒前
20秒前
一直向前发布了新的文献求助10
23秒前
如意的泥猴桃完成签到,获得积分10
25秒前
土拨鼠完成签到 ,获得积分10
25秒前
26秒前
科目三应助林好事采纳,获得10
26秒前
叶子完成签到,获得积分10
26秒前
26秒前
Newt发布了新的文献求助10
27秒前
29秒前
李健应助青黛采纳,获得10
30秒前
小四发布了新的文献求助10
33秒前
Sky36001发布了新的文献求助20
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531914
关于积分的说明 11255516
捐赠科研通 3270597
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190