化学
多米诺骨牌
诺博南
色酮
钯
催化作用
废止
有机化学
部分
组合化学
作者
Fei Li,Huimin Li,Ren-Feng Xiu,Jin-Ke Zhang,Bao‐Dong Cui,Nan‐Wei Wan,Yong‐Zheng Chen,Wen‐Yong Han
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-12-16
卷期号:24 (51): 9392-9397
被引量:11
标识
DOI:10.1021/acs.orglett.2c03713
摘要
Reported herein is a novel palladium-catalyzed [2 + 2 + 1] domino annulation of 3-iodochromones, bridged olefins, and dimethyl squarate allowing the construction of chromone-containing polycyclic compounds in good to high yields. Importantly, dimethyl squarate is first employed as the solid C1 source in organic synthesis. Gram-scale experiments, late-stage modification of natural products, as well as transformations of products show potential for further synthetic elaborations.
科研通智能强力驱动
Strongly Powered by AbleSci AI