医学
食管切除术
食管癌
胃肠病学
内科学
多元分析
癌症
临床意义
外科
作者
Suguru Maruyama,Akihiko Okamura,Yasukazu Kanie,Kinya Kuriyama,Kei Sakamoto,Jun Kanamori,Yu Imamura,Masayuki Watanabe
标识
DOI:10.1007/s00423-023-02977-3
摘要
Recent reports have suggested that basophils influence allergic reactions and tumor immunity. In this study, we aimed to elucidate the association between preoperative circulating basophil (CB) counts and the outcomes of patients who underwent esophagectomy for esophageal cancer.A total of 783 consecutive patients who underwent esophagectomy for esophageal cancer were eligible. The clinicopathological factors and prognoses were compared between the groups stratified by the preoperative counts of CB.There were more advanced clinical T and N stages in the low CB group than in the high CB group (P = 0.01 and = 0.04, respectively). The incidences of postoperative complications were comparable between the groups. The low CB count was associated with unfavorable overall and recurrence-free survivals (P = 0.04 and 0.01, respectively). In the multivariate analysis, low CB count was one of the independent prognostic factors for poor recurrence-free survival (HR 1.33; 95% CI 1.04-1.70; P = 0.02). In addition, hematogenous recurrence occurred more frequently in the low CB group than in the high CB group (57.6% vs. 41.4%, P = 0.04).A preoperative low CB count was an unfavorable prognosticator in patients who underwent esophagectomy for esophageal cancer.
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