谵妄
围手术期
痴呆
医学
神经炎症
疾病
病因学
重症监护医学
术后认知功能障碍
入射(几何)
淀粉样蛋白(真菌学)
麻醉
精神科
内科学
病理
认知
物理
光学
作者
Tyler Reekes,Michael J. Devinney,Miles Berger
标识
DOI:10.1016/j.bja.2023.05.009
摘要
Postoperative delirium is a particularly debilitating complication of surgery and perioperative care. Although the aetiology of postoperative delirium is not entirely understood, recent evidence suggests that Alzheimer's disease and related dementias pathology plays an important role in the development of postoperative delirium. A recent study evaluating postoperative changes in plasma beta amyloid (Aβ) levels found increased Aβ across the postoperative period, but the association with postoperative delirium incidence and severity was variable. These findings support the idea that Alzheimer's disease and related dementias pathology in combination with blood–brain barrier dysfunction and neuroinflammation may impart risk for postoperative delirium.
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