化学
催化作用
芳基
烷基
镍
锰
配体(生物化学)
药物化学
赫克反应
有机化学
组合化学
光化学
生物化学
受体
作者
Minling Xü,Lijia Qian,Gang Zou
标识
DOI:10.1016/j.mcat.2023.113291
摘要
An air-tolerant reductive Heck reaction of alkyl/aryl halides with α, β-unsaturated esters, nitriles and amides catalyzed by simple nickel bromide has been developed by using manganese as reductant in refluxing acetonitrile. Water plays a double-face role in the catalytic process, hydrolysis of the enolate and/or C-tautomer intermediates to afford the conjugate adducts while suppressing the catalysis at high concentration. The scope and limitations of the nickel-catalyzed manganese-mediated process have been demonstrated by more than 40 examples, showing large steric effects and good functional group compatibility except for reduction-sensitive ones.
科研通智能强力驱动
Strongly Powered by AbleSci AI