电源1
对氧磷酶
姜黄素
酶
芳基二烷基磷酸酶
基因
基因表达
药理学
生物化学
化学
生物
分子生物学
基因型
作者
Fatemeh Hamedi,Mohammad Alizadeh,Sorayya Kheirouri,Roghayeh Molani‐Gol
标识
DOI:10.1016/j.prostaglandins.2024.106849
摘要
Paraoxonase (PON) proteins have various hydrolytic activities. The PON family is able to detoxify oxidized low-density lipoprotein. Additionally, differentiation of monocytes into macrophages, as the first stage in the development of atherosclerosis, is suppressed by PON 1. The effects of polyphenols including curcumin on PON1 have been investigated in studies. In this study, our main goal is to investigate curcumin's effect on PON1 protein levels, gene expression, and enzyme activity in animal interventional studies. The literature was searched through the online databases including PubMed, SCOPUS, Embase, and Google Scholar until May 2022. Curcumin administration can increase the PON1 enzyme activity. Also, it probably has a positive role in increasing the PON1 gene expression. However, concerning the PON1 protein values, results are contradictory. The findings of this study suggested positive role of curcumin in increasing PON1 enzyme activities, gene expression, and protein levels. Data are available from the corresponding author ([email protected])
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