糖基
立体选择性
化学
组合化学
有机化学
催化作用
作者
Yanjing Li,Yubiao Tian,Demeng Xie,Yingwei Wang,Dawen Niu
摘要
Despite their critical importance in drug development and biochemistry, efficiently synthesizing α-glycosyl azides has continued to pose significant challenges. In this report, we introduce a universal and practical radical reaction for the stereoselective synthesis of α-glycosyl azides using bench-stable allyl glycosyl sulfones as the donor. This method is characterized by its mild reaction conditions, high stereoselectivity, and extensive scope of glycosyl units. Moreover, the accessibility of several structurally complex drug-sugar conjugates underscores the practicality of our approach.
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