坏死性下垂
发病机制
椎间盘
变性(医学)
医学
神经科学
病理
生物
解剖
程序性细胞死亡
细胞凋亡
遗传学
作者
Ruiqiong Ran,Wei Song,Yong-Qiang Shi,Wei Song,Wei Song,Yong-Qiang Shi,Kaisheng Zhou,Haihong Zhang
标识
DOI:10.1016/j.intimp.2024.112616
摘要
Intervertebral disc degeneration (IDD) is the leading cause of low back pain, which is one of the major factors leading to disability and severe economic burden. Necroptosis is an important form of programmed cell death (PCD), a highly regulated caspase-independent type of cell death that is regulated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL)-mediated, play a key role in the pathophysiology of various inflammatory, infectious and degenerative diseases. Recent studies have shown that necroptosis plays an important role in the occurrence and development of IDD. In this review, we provide an overview of the initiation and execution of necroptosis and explore in depth its potential mechanisms of action in IDD. The analysis focuses on the connection between NP cell necroptosis and mitochondrial dysfunction-oxidative stress pathway, inflammation, endoplasmic reticulum stress, apoptosis, and autophagy. Finally, we evaluated the possibility of treating IDD by inhibiting necroptosis, and believed that targeting necroptosis may be a new strategy to alleviate the symptoms of IDD.
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