脚手架
再生(生物学)
材料科学
Crystal(编程语言)
化学工程
纳米技术
生物医学工程
细胞生物学
计算机科学
生物
工程类
程序设计语言
作者
Sungwoo Cho,Kang Suk Lee,Kyubae Lee,Hye‐Seon Kim,Suji Park,Seung Eun Yu,Hyun‐Su Ha,Sewoom Baek,Jueun Kim,Hyun-Jae Kim,Ji Youn Lee,Sangmin Lee,Hak‐Joon Sung
出处
期刊:Small
[Wiley]
日期:2024-06-10
标识
DOI:10.1002/smll.202401989
摘要
Abstract The minimally invasive deployment of scaffolds is a key safety factor for the regeneration of cartilage and bone defects. Osteogenesis relies primarily on cell‐matrix interactions, whereas chondrogenesis relies on cell–cell aggregation. Bone matrix expansion requires osteoconductive scaffold degradation. However, chondrogenic cell aggregation is promoted on the repellent scaffold surface, and minimal scaffold degradation supports the avascular nature of cartilage regeneration. Here, a material satisfying these requirements for osteochondral regeneration is developed by integrating osteoconductive hydroxyapatite (HAp) with a chondroconductive shape memory polymer (SMP). The shape memory function‐derived fixity and recovery of the scaffold enabled minimally invasive deployment and expansion to fill irregular defects. The crystalline phases on the SMP surface inhibited cell aggregation by suppressing water penetration and subsequent protein adsorption. However, HAp conjugation SMP (H‐SMP) enhanced surface roughness and consequent cell‐matrix interactions by limiting cell aggregation using crystal peaks. After mouse subcutaneous implantation, hydrolytic H‐SMP accelerated scaffold degradation compared to that by the minimal degradation observed for SMP alone for two months. H‐SMP and SMP are found to promote osteogenesis and chondrogenesis, respectively, in vitro and in vivo, including the regeneration of rat osteochondral defects using the binary scaffold form, suggesting that this material is promising for osteochondral regeneration.
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