Monitoring of inflammatory blood biomarkers in foals with Rhodococcus Equi pneumonia during antimicrobial treatment

马红球菌 抗菌剂 肺炎 医学 微生物学 免疫学 内科学 生物 生物化学 毒力 基因
作者
Ömer Deniz,Gencay Ekinci,Ali Cesur Onmaz,Fatih Mehmet Derelli,Francesco Fazio,Francesca Aragona,René van den Hoven
出处
期刊:Journal of Equine Veterinary Science [Elsevier BV]
卷期号:138: 105103-105103
标识
DOI:10.1016/j.jevs.2024.105103
摘要

Rhodococcus equi (R. equi), a gram-positive facultative intracellular pathogen, is a common cause of pneumonia in foals and represents a major cause of disease and death. The aim of the present study was to investigate the time-depended changes in White Blood Cells (WBC), basophils (Baso), neutrophils (Neu), lymphocytes (Lymf), monocytes (Mon), eosinophils (Eos), platelet (PLT) counts, fibrinogen (Fbg) concentration, interferon (IFN-α, IFN-γ) and interleukins (IL-2 and IL-10) in foals with clinical R. equi pneumonia. The main treatment was with azithromycin-rifampicin for 14 days. Blood was sampled prior to, 7 and 14 days after starting therapy. Treatment was associated with significantly decreased counts of WBC, (25.6 ± 6.7 and 14.2 ± 2,7×103/mL), Neu (18.6 ±6.2 and 10.7 ± 3.1×103/ml), Mon (1.5 ± 0.5 and 0.9 ±0.2×103/ml) and Fbg (539±124 and 287 ± 26 g/dl) between day 0 and day 14. IL-2 and IL-10 concentrations were significantly increased (P=0.028, P=0.013, respectively) after treatment, whereas IFN-α and IFN-γ concentrations were not. The diagnostic potentials of INF-α, INF-γ, IL-2 and IL-10 per se seems not very high, however, the study suggests that the activity change of selected interleukins in the course of the disease may be associated with amelioration. We concluded that patterns of serum concentration changes of INF-α, INF-γ, IL-2 and IL-10 may help in the study of the innate immune response in foals during infection and treatment of R. equi pneumonia.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Villanellel发布了新的文献求助10
刚刚
程艳完成签到 ,获得积分10
1秒前
MINGHUI完成签到,获得积分10
2秒前
2秒前
子车半烟完成签到,获得积分10
2秒前
4秒前
淳于安筠完成签到,获得积分10
4秒前
雨晴完成签到,获得积分10
7秒前
jbq发布了新的文献求助10
7秒前
joshar完成签到,获得积分10
7秒前
8秒前
量子星尘发布了新的文献求助10
10秒前
blueblue完成签到,获得积分10
12秒前
落后秋烟完成签到,获得积分10
14秒前
大橙子发布了新的文献求助10
15秒前
LMY完成签到 ,获得积分10
15秒前
Betty完成签到 ,获得积分10
15秒前
NexusExplorer应助jbq采纳,获得10
16秒前
渔渔完成签到 ,获得积分10
16秒前
17秒前
Tangyartie完成签到 ,获得积分10
17秒前
skbkbe完成签到 ,获得积分10
18秒前
陈俊雷完成签到 ,获得积分0
19秒前
阿苗完成签到,获得积分10
20秒前
神勇的天问完成签到 ,获得积分10
21秒前
21秒前
advance完成签到,获得积分10
21秒前
李cc发布了新的文献求助10
22秒前
蒋念寒发布了新的文献求助10
23秒前
Sindy完成签到,获得积分10
23秒前
彭于晏应助HH采纳,获得30
25秒前
25秒前
朴实的小萱完成签到 ,获得积分10
26秒前
科研通AI5应助哭泣笑柳采纳,获得10
26秒前
26秒前
温暖的蚂蚁完成签到 ,获得积分10
29秒前
dhn123完成签到,获得积分10
29秒前
ccx完成签到,获得积分10
29秒前
30秒前
biofresh发布了新的文献求助30
30秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022