One size might fit all: Indole-3-propionic acid potentiates pan-cancer immunotherapy

Microbial-based therapies have the potential to combat immunotherapy resistance, extending the boundaries of oncological therapeutics. In a recent issue of Cell, Jia et al. demonstrates an example of microbial collaboration to produce a postbiotic that promotes the stemness program of CD8+ T cells to augment immunotherapy at the pan-cancer level. Microbial-based therapies have the potential to combat immunotherapy resistance, extending the boundaries of oncological therapeutics. In a recent issue of Cell, Jia et al. demonstrates an example of microbial collaboration to produce a postbiotic that promotes the stemness program of CD8+ T cells to augment immunotherapy at the pan-cancer level. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancerJia et al.CellMarch 14, 2024In BriefL. johnsonii and C. sporogenes collaborate to produce indole-3-propionic acid, which modulates CD8+ T cell stemness by increasing H3K27 acetylation at the Tcf7 super-enhancer, thereby enhancing the anti-tumor effect of immune checkpoint blockade in pan-cancer. Full-Text PDF