Safety, tolerability, and immunogenicity of an adult pneumococcal conjugate vaccine, V116 (STRIDE-3): a randomised, double-blind, active comparator controlled, international phase 3 trial

耐受性免疫原性医学肺炎球菌病结合肺炎球菌结合疫苗儿科内科学不利影响肺炎链球菌免疫学抗体抗生素微生物学数学分析生物数学

作者

Heather Platt,Christopher Bruno,Erik Buntinx,Enrique Pelayo,Diego García-Huidobro,Elizabeth A Barranco-Santana,Folke Sjöberg,Joon Young Song,Carlos G. Grijalva,Walter A. Orenstein,Leslie Morgan,Doreen Fernsler,Weifeng Xu,Muhammad Waleed,Jianing Li,Ulrike K. Buchwald,Michael Abdel-Malek,Jeffrey Adelglass,Sady Alpizar,Duane C. Anderson,Charles P. Andrews,Helena Hervius Askling,Jeffrey B. Baker,Mira Baron,Elizabeth A Barranco-Santana,John Beckes,James H. Bergthold,Peter Bosson,Erik Buntinx,Larry M. Bush,David Butuk,Edgardo F. Cartagena Ayala,Hee Jung Choi,Jung‐Hyun Choi,Won Suk Choi,Young Hwa Choi,James R. Clark,Oliver A. Cornely,Steve E. Cox,Nizar Daboul,Luis I. De La Cruz,Pamela De Silva,Olaf Degen,Valentine M. Ebuh,Stanton R. Elzi,Thomas Fiel,William Fitzgibbons,Neil J. Fraser,George Hartley Freeman,Christopher Galloway,Diego García-Huidobro,Juan Carlos Garza,Anil George,Carl Griffin,Sridhar Guduri,Rahmet Güner,Elizabeth Gunner,Enrique Hanabergh,Charles Harper,Kathleen Mullan Harris,John Matthew Hemmersmeier,John M. Hill,Ching‐Tai Huang,Kuo‐Chin Huang,Chad Roger Huberty,Bejamin James Image,Margret Jandl,Jr. Johnston William Henry,Jackie Kamerbeek,Oğuz Karabay,Jae‐Hoon Ko,İftihar Köksal,Ki Tae Kwon,Amber Leah,Dong‐Gun Lee,Jacob Lee,Thomas Lenzmeier,Denissa Loh,Rafael Lupercio,A. Luts,Thomas A. Lutz,José Luis Martínez,Renae Mayer,Vicki E. Miller,Javier O Morales-Ramirez,Manuel Múñoz,J. Navarro,Larry Lee Odekirk,Patrick Odia,Alberto Odio,Matthew O’Sullivan,Minesh Arun Patel,Enrique Pelayo,Carlos Perez Cortes,Syed Pervaiz,J Probst,Dean Richard Quinn,Kathryn R. Rigonan,Nicolas Rosario-Matos,Jeffrey B. Rosen,Andrej Sannesten,Axel Schaefer,Sven Schellberg,Manjoo Sharma,Lawrence D. Sher,Hyejin Shi,Gerald Shockey,R. N. Singh,Folke Sjöberg,Bruce A. Smith,Christohper A. Smith,Deon Smith,Susan Smith,Joon Young Song,Jonathan Staben,Kenneth Steil,Chien‐Tien Su,Serhat Ünal,S.I. Wie,Priyantha N. Wijewardane,Michael J. Williams,Thomas Wolf,Yi-Ching Yang,Joon‐Sup Yeom

出处

期刊：Lancet Infectious Diseases [Elsevier]
日期：2024-07-01 卷期号：24 (10): 1141-1150 被引量：3

链接

nih.govdoi.org

标识

DOI：10.1016/s1473-3099(24)00344-x

摘要

The same pneumococcal conjugate vaccines (PCVs) have been used in adults and children in many settings. Differences in the epidemiology of pneumococcal disease between populations necessitates an adult-specific PCV. We aimed to assess the safety, tolerability, and immunogenicity of V116, an investigational 21-valent PCV designed for adults.

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Safety, tolerability, and immunogenicity of an adult pneumococcal conjugate vaccine, V116 (STRIDE-3): a randomised, double-blind, active comparator controlled, international phase 3 trial

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