A combined histopathologic and radiologic study has been performed on lungs obtained at autopsy to record the frequency and patterns of pulmonary metastasis in patients dying with a malignant neoplasm. The frequency of metastasis was higher and the patterns of tumor growth were more variable than expected, often making radiologic differentiation of tumor from nonneoplastic lesions difficult. The findings are discussed with particular reference to the problems of making an in vivo radiologic diagnosis of secondary tumor in the lung even with computed tomography.