Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures

肝移植 医学 吻合 移植 胆管 病理 胃肠病学 内科学 外科
作者
Sanna op den Dries,Andrie C. Westerkamp,Negin Karimian,Annette S.H. Gouw,Bote G. Bruinsma,James F. Markmann,Ton Lisman,Heidi Yeh,Korkut Uygun,Paulo N. Martins,Robert J. Porte
出处
期刊:Journal of Hepatology [Elsevier]
卷期号:60 (6): 1172-1179 被引量:169
标识
DOI:10.1016/j.jhep.2014.02.010
摘要

Background & Aims

The peribiliary glands of large bile ducts have been identified as a niche of progenitor cells that contribute to regeneration of biliary epithelium after injury. We aimed to determine whether injury to the peribiliary glands of donor livers is a risk factor for development of non-anastomotic biliary strictures (NAS) after liver transplantation.

Methods

In 128 liver transplant procedures, biopsies were taken from the donor bile duct and injury was assessed using an established histological grading system. Histological severity of injury was subsequently compared in liver grafts that later developed biliary structures vs. uncomplicated liver grafts.

Results

Luminal biliary epithelial loss >50% was observed in 91.8% of the grafts before transplantation, yet NAS occurred in only 16.4%. Periluminal peribiliary glands were more severely injured than deep peribiliary glands located near the fibromuscular layer (>50% loss in 56.9% vs. 17.5%, respectively; p<0.001). Injury of deep peribiliary glands was more prevalent and more severe in livers that later developed NAS, compared to grafts without NAS (>50% loss in 50.0% vs. 9.8%, respectively; p=0.004). In parallel, injury of the peribiliary vascular plexus was more severe in livers that developed NAS, compared to grafts without NAS (>50% vascular changes in 57.1% vs. 20.3%; p=0.006).

Conclusion

Injury of peribiliary glands and vascular plexus before transplantation is strongly associated with the occurrence of biliary strictures after transplantation. This suggests that insufficient regeneration due to loss of peribiliary glands or impaired blood supply may explain the development of biliary strictures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
XIOUU完成签到,获得积分10
2秒前
2秒前
3秒前
积极的千雁完成签到,获得积分10
3秒前
落雁完成签到,获得积分20
3秒前
4秒前
5秒前
5秒前
fuguier发布了新的文献求助10
6秒前
steventj完成签到,获得积分10
6秒前
vikey完成签到 ,获得积分10
7秒前
Dsivan发布了新的文献求助10
7秒前
葱花香菜发布了新的文献求助10
10秒前
橙猫猫发布了新的文献求助10
10秒前
Tysonqu完成签到,获得积分10
12秒前
anderson1738完成签到,获得积分10
13秒前
电致阿光完成签到,获得积分10
15秒前
星奕完成签到 ,获得积分10
16秒前
倪小呆完成签到 ,获得积分10
17秒前
华仔应助愿不负丶采纳,获得10
19秒前
桐桐应助浪迹天涯采纳,获得10
19秒前
美满的小蘑菇完成签到 ,获得积分10
20秒前
20秒前
伶俐的春天完成签到 ,获得积分10
22秒前
自觉画笔完成签到 ,获得积分10
23秒前
23秒前
康康舞曲完成签到 ,获得积分10
23秒前
Duckseid完成签到,获得积分10
25秒前
龙痕完成签到,获得积分10
25秒前
巴巴拉拉巴拉完成签到 ,获得积分10
26秒前
浥青竹完成签到,获得积分10
26秒前
鲁滨逊完成签到 ,获得积分10
26秒前
27秒前
CQ完成签到 ,获得积分10
27秒前
明理小凝完成签到 ,获得积分10
27秒前
Star完成签到,获得积分10
29秒前
寒战完成签到 ,获得积分10
30秒前
30秒前
畅快的念烟完成签到,获得积分10
31秒前
song_song发布了新的文献求助10
32秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 720
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Typology of Conditional Constructions 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3566811
求助须知:如何正确求助?哪些是违规求助? 3139560
关于积分的说明 9431989
捐赠科研通 2840353
什么是DOI,文献DOI怎么找? 1560990
邀请新用户注册赠送积分活动 730141
科研通“疑难数据库(出版商)”最低求助积分说明 717855