医学
甲氨蝶呤
抗代谢物
化疗
白血病
淋巴瘤
癌症
疾病
乳腺癌
骨肉瘤
肿瘤科
内科学
免疫学
药理学
癌症研究
作者
Jacques Jolivet,Kenneth H. Cowan,Gregory A. Curt,Neil J. Clendeninn,Bruce A. Chabner
标识
DOI:10.1056/nejm198311033091805
摘要
METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer.1 It has also become an important therapeutic alternative in the treatment of severe psoriasis2 and in the suppression of graft-versus-host disease after bone-marrow transplantation,3 as well as in the experimental treatment of various rheumatic diseases after primary therapy has failed.4 Through pharmacologic research we have gained an understanding of the basic steps in the action of methotrexate, including its transport across cell membranes, its intracellular . . .
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