已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

An 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality Program for Chronic Low Back Pain: Double-Blind, Randomized, Placebo-Controlled Trial Conducted During COVID-19

物理疗法 医学 慢性疼痛 心情 随机对照试验 剧痛 安慰剂 物理医学与康复 临床心理学 外科 病理 替代医学
作者
Laura Martínez García,Brandon Birckhead,Parthasarathy Krishnamurthy,Josh Sackman,Ian Mackey,Robert G. Louis,Vafi Salmasi,Todd Maddox,Beth D. Darnall
出处
期刊:Journal of Medical Internet Research [JMIR Publications]
卷期号:23 (2): e26292-e26292 被引量:82
标识
DOI:10.2196/26292
摘要

Background Chronic low back pain is the most prevalent chronic pain condition worldwide and access to behavioral pain treatment is limited. Virtual reality (VR) is an immersive technology that may provide effective behavioral therapeutics for chronic pain. Objective We aimed to conduct a double-blind, parallel-arm, single-cohort, remote, randomized placebo-controlled trial for a self-administered behavioral skills-based VR program in community-based individuals with self-reported chronic low back pain during the COVID-19 pandemic. Methods A national online convenience sample of individuals with self-reported nonmalignant low back pain with duration of 6 months or more and with average pain intensity of 4 or more/10 was enrolled and randomized 1:1 to 1 of 2 daily (56-day) VR programs: (1) EaseVRx (immersive pain relief skills VR program); or (2) Sham VR (2D nature content delivered in a VR headset). Objective device use data and self-reported data were collected. The primary outcomes were the between-group effect of EaseVRx versus Sham VR across time points, and the between–within interaction effect representing the change in average pain intensity and pain-related interference with activity, stress, mood, and sleep over time (baseline to end-of-treatment at day 56). Secondary outcomes were global impression of change and change in physical function, sleep disturbance, pain self-efficacy, pain catastrophizing, pain acceptance, pain medication use, and user satisfaction. Analytic methods included intention-to-treat and a mixed-model framework. Results The study sample was 179 adults (female: 76.5%, 137/179; Caucasian: 90.5%, 162/179; at least some college education: 91.1%, 163/179; mean age: 51.5 years [SD 13.1]; average pain intensity: 5/10 [SD 1.2]; back pain duration ≥5 years: 67%, 120/179). No group differences were found for any baseline variable or treatment engagement. User satisfaction ratings were higher for EaseVRx versus Sham VR (P<.001). For the between-groups factor, EaseVRx was superior to Sham VR for all primary outcomes (highest P value=.009), and between-groups Cohen d effect sizes ranged from 0.40 to 0.49, indicating superiority was moderately clinically meaningful. For EaseVRx, large pre–post effect sizes ranged from 1.17 to 1.3 and met moderate to substantial clinical importance for reduced pain intensity and pain-related interference with activity, mood, and stress. Between-group comparisons for Physical Function and Sleep Disturbance showed superiority for the EaseVRx group versus the Sham VR group (P=.022 and .013, respectively). Pain catastrophizing, pain self-efficacy, pain acceptance, prescription opioid use (morphine milligram equivalent) did not reach statistical significance for either group. Use of over-the-counter analgesic use was reduced for EaseVRx (P<.01) but not for Sham VR. Conclusions EaseVRx had high user satisfaction and superior and clinically meaningful symptom reduction for average pain intensity and pain-related interference with activity, mood, and stress compared to sham VR. Additional research is needed to determine durability of treatment effects and to characterize mechanisms of treatment effects. Home-based VR may expand access to effective and on-demand nonpharmacologic treatment for chronic low back pain. Trial Registration ClinicalTrials.gov NCT04415177; https://clinicaltrials.gov/ct2/show/NCT04415177 International Registered Report Identifier (IRRID) RR2-10.2196/25291

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
lizigongzhu发布了新的文献求助10
5秒前
三井库里发布了新的文献求助10
7秒前
念初发布了新的文献求助10
8秒前
桐桐应助水之冬采纳,获得10
9秒前
10秒前
废式脂肪发布了新的文献求助10
13秒前
13秒前
今后应助hhhi采纳,获得10
15秒前
迷路翠绿发布了新的文献求助10
17秒前
漂亮白枫发布了新的文献求助10
18秒前
废式脂肪完成签到,获得积分10
20秒前
NexusExplorer应助三井库里采纳,获得10
21秒前
顾矜应助桀桀桀采纳,获得10
24秒前
26秒前
26秒前
30秒前
今后应助漂亮白枫采纳,获得10
33秒前
35秒前
ruler发布了新的文献求助10
37秒前
桀桀桀发布了新的文献求助10
38秒前
一直向前发布了新的文献求助10
40秒前
bkagyin应助Karol采纳,获得10
40秒前
41秒前
42秒前
ZGH完成签到,获得积分10
42秒前
小二郎应助是小小李哇采纳,获得10
43秒前
cgg完成签到 ,获得积分10
45秒前
46秒前
杰jj发布了新的文献求助10
46秒前
英俊的铭应助科研通管家采纳,获得10
46秒前
orixero应助WuYiHHH采纳,获得10
46秒前
完美世界应助科研通管家采纳,获得10
46秒前
科研通AI5应助科研通管家采纳,获得10
46秒前
科研通AI5应助科研通管家采纳,获得10
46秒前
我是老大应助科研通管家采纳,获得10
46秒前
科研通AI2S应助科研通管家采纳,获得10
46秒前
上官若男应助科研通管家采纳,获得10
46秒前
47秒前
48秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989918
求助须知:如何正确求助?哪些是违规求助? 3532013
关于积分的说明 11255831
捐赠科研通 3270829
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882233
科研通“疑难数据库(出版商)”最低求助积分说明 809216