医学
模式
放射治疗
临床试验
药物治疗
重症监护医学
心理干预
梅德林
工作队
临床实习
内科学
病理
物理疗法
精神科
社会科学
公共行政
社会学
政治学
法学
作者
Michael Weller,Martin J. van den Bent,Matthias Preusser,Émilie Le Rhun,Jörg C. Tonn,Giuseppe Minniti,Martin Bendszus,Carmen Balañá,Olivier Chinot,Linda Dirven,Pim J. French,Monika E. Hegi,Asgeir Store Jakola,Michael Platten,Patrick Roth,Roberta Rudà,Susan Short,Marion Smits,Martin Taphoorn,Andreas von Deimling
标识
DOI:10.1038/s41571-020-00447-z
摘要
Abstract In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy — Not Officially WHO (cIMPACT-NOW). With regard to therapy, we formulated recommendations based on the results from the latest practice-changing clinical trials and also provide guidance for neuropathological and neuroradiological assessment. In these guidelines, we define the role of the major treatment modalities of surgery, radiotherapy and systemic pharmacotherapy, covering current advances and cognizant that unnecessary interventions and expenses should be avoided. This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers.
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