化学
内生
荧光
甲醛
活细胞
选择性
活体细胞成像
联氨(抗抑郁剂)
生物物理学
细胞
生物化学
细胞生物学
催化作用
生物
量子力学
物理
作者
Lei Gu,Yonghe Tang,Weiying Lin
出处
期刊:Tetrahedron
[Elsevier BV]
日期:2020-11-29
卷期号:78: 131808-131808
被引量:13
标识
DOI:10.1016/j.tet.2020.131808
摘要
A new turn-on fluorescent probe, named as NaFP was structured with hydrazine group as a recognition site for detecting formaldehyde (FA) in living cells. The probe NaFP has large turn-on signal and high selectivity for FA. In addition, the results of cell imaging experiments indicate that NaFP could image exogenous/endogenous FA in living cells. The new highly selective fluorescence probe ( NaFP ) was designed and synthesized for monitoring endogenous formaldehyde of the living cells. • A novel naphthalimide-based formaldehyde probe was designed. • The probe NaFP with highly selective detection to formaldehyde. • The probe NaFP had achieved in monitoring exogenous and endogenous formaldehyde in living cells. • The endoplasmic reticulum stress could lead to increased concentration of formaldehyde was verified by using the probe NaFP .
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