洛哌丁胺
便秘
胃肠道
胃肠病学
乳酸菌
肠道菌群
双歧杆菌
内科学
胃排空
医学
粪便
胃
小肠
大肠
腹泻
生理学
生物
微生物学
食品科学
免疫学
发酵
作者
Qi Zhang,Dian Zhong,Rui Sun,Yang Zhang,Ronald B. Pegg,Geng Zhong
标识
DOI:10.1016/j.carbpol.2020.117418
摘要
Constipation is one of the most prevalent gastrointestinal tract diseases. Konjac glucomannan (KGM) dietotherapy can effectively relieve the clinical symptoms of patients with constipation. However, the causal relationship among KGM, constipation and different gastrointestinal microbiome (i.e., the stomach {St}, small intestine {S}, and large intestine {L}) remains poorly understood. In this study, constipated mice were treated with KGM (75, 150, 300 mg/kg bw). Results showed that KGM treatment improved the general physiological state, fecal character, small intestinal propulsive rate, gastric emptying rate, MTL and AchE activities, ET-1, 5-HT, and NO levels, and SCFA concentrations. KGM in the diets of constipated mice reduced the diversity of St and S microbiota, while increased those in the L. The KGM intervention regulated the microbiota profile, which afterwards was closer to the normal mouse group: confirmation was provided by different changes of bacteria like Lactobacillus, Bifidobacterium and Allobaculum spp et al.
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