Nrf-2 mediated heme oxygenase-1 activation contributes to the anti-inflammatory and renal protective effects of Ginkgo biloba extract in diabetic nephropathy

糖尿病肾病 突触素 银杏 尼福林 血红素加氧酶 足细胞 药理学 化学 内分泌学 内科学 肾功能 血红素 医学 生物化学 蛋白尿
作者
Ting‐Ting Chang,Yi-An Chen,Szu‐Yuan Li,Jaw‐Wen Chen
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:266: 113474-113474 被引量:28
标识
DOI:10.1016/j.jep.2020.113474
摘要

Ginkgo biloba extract (GbE) is derived from a medicinal plant and suggested as a treatment for diabetic nephropathy (DN), but the mechanism was not clarified. The present study investigated whether GbE prevented DN via activation of heme oxygenase (HO)-1. Streptozotocin-induced diabetic mice were fed a high-fat diet to generate DN. Human and murine podocytes were used for the in vitro study. GbE improved renal function via decreasing glomerular hypertrophy, the kidney/body weight ratio, and albuminuria in DN mice. GbE reversed the reduction of synaptopodin and nephrin and enhanced HO-1 expression in the kidneys of DN mice. GbE decreased the enhancement of TNF-α, IL-6, fibronectin, and lipid accumulation in the glomeruli of DN mice. GbE attenuated the uptake of oxidized low-density lipoprotein and reduced the production of ROS in high glucose-stimulated podocytes, and HO-1 inhibitor treatment abrogated the protective effects of GbE. Nuclear factor erythroid 2-related factor 2 (Nrf-2) siRNA significantly abolished the beneficial effects of GbE via decreased HO-1 expression and enhanced TNF-α and IL-6 levels. GbE protected podocytes against hyperglycemia and prevented the development of DN via Nrf-2/HO-1 activation. Our findings provide further mechanistic insight into the potential use of GbE in clinical DN.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Jay完成签到,获得积分10
1秒前
FashionBoy应助笑点低诗桃采纳,获得10
2秒前
2秒前
青柠完成签到,获得积分10
3秒前
258369发布了新的文献求助10
5秒前
Ava应助俏皮的白柏采纳,获得10
6秒前
James- LPY发布了新的文献求助10
7秒前
千余发布了新的文献求助10
10秒前
anan完成签到,获得积分10
10秒前
13秒前
13秒前
14秒前
15秒前
莹0000完成签到,获得积分10
16秒前
17秒前
YamDaamCaa应助科研通管家采纳,获得30
18秒前
YamDaamCaa应助科研通管家采纳,获得30
19秒前
桐桐应助科研通管家采纳,获得10
19秒前
19秒前
烟花应助科研通管家采纳,获得10
19秒前
星辰大海应助科研通管家采纳,获得10
19秒前
19秒前
moon发布了新的文献求助10
19秒前
幽默尔蓝发布了新的文献求助10
19秒前
默默的裘完成签到,获得积分10
21秒前
科研通AI2S应助liuzengzhang666采纳,获得10
22秒前
深情安青应助lll采纳,获得10
23秒前
闪闪完成签到,获得积分10
24秒前
AST灰烬发布了新的文献求助10
24秒前
25秒前
鲤跃发布了新的文献求助10
27秒前
28秒前
29秒前
情怀应助moon采纳,获得10
29秒前
29秒前
lll应助文件撤销了驳回
32秒前
32秒前
陈七七完成签到 ,获得积分10
33秒前
34秒前
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035