A new predicting model of preeclampsia based on peripheral blood test value.

子痫前期 医学 天冬氨酸转氨酶 内科学 血尿素氮 肌酐 胱抑素C 逻辑回归 纤维蛋白原 平均血小板体积 产科 尿酸 胃肠病学 肾功能 胎龄 内分泌学 怀孕 血小板 碱性磷酸酶 生物 遗传学 生物化学
作者
Qianqian Han,Wenfei Zheng,Xiao Guo,D Zhang,Liu Hf,Yu Lan,Jian Yan
出处
期刊:European Review for Medical and Pharmacological Sciences [Verduci Editore]
卷期号:24 (13): 7222-7229 被引量:5
标识
DOI:10.26355/eurrev_202007_21874
摘要

Objective To identify laboratory markers among platelet indices, coagulation parameters, blood lipid parameters, and liver/kidney function variables that can be used to predict preeclampsia. Patients and methods We studied records of 568 women with preeclampsia, gestational hypertension (GH), or normal term pregnancies hospitalized in the Obstetrics Department of the Fujian Maternal and Child Health Hospital from September 2014 to September 2018. We divided the patients' records into three groups (216 with preeclampsia, 136 with gestational hypertension, and 216 with normal pregnancies). We conducted retrospective analyses to compare variable measurements between the groups and find correlations. We looked into maternal pre-onset platelet indices, coagulation parameters (thrombin time [TT], fibrinogen [FIB]), biochemical parameters (total cholesterol [TC], triglycerides [TG], high-density lipoproteins [HDL], alanine transaminase [ALT], serum creatinine [CRE], blood urea nitrogen [BUN], uric acid [UA]), maternal complications, and perinatal outcomes. In addition to our statistical analysis, we trained a back-propagation (BP) neural network to identify the strongest predictors of preeclampsia. Results We found significant differences among the groups in terms of values for PLT, MPV, PDW, PLCR, TT, FIB, TG, LDH, BUN, and others. After adjusting for confounding factors in a multivariate ordered logistic regression model, we found that mean values for MPV, BUN, TG, and LDH can independently predict the risk of preeclampsia (the OR values were 1.858, 1.583, 1.104, and 1.020, respectively), the C-index (concordance statistic) was 0.73. Also, our BP neural network derived ALB, MPV, BUN, LDH and TG as the strongest predictors of preeclampsia. Conclusions MPV, TG, LDH, and BUN can help establish the risk for the development of preeclampsia to apply active measures and improve maternal and perinatal outcomes. The BP neural network can be used to study predictive models of preeclampsia.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
重要忆秋完成签到,获得积分10
1秒前
yy发布了新的文献求助10
1秒前
wwm98656完成签到,获得积分10
4秒前
4秒前
totpto完成签到,获得积分20
5秒前
7秒前
My完成签到,获得积分10
7秒前
孙颖莎粉丝完成签到,获得积分10
7秒前
尼古拉耶维奇完成签到,获得积分10
7秒前
阿卡宁发布了新的文献求助10
8秒前
9秒前
温柔翰完成签到,获得积分10
10秒前
文龙完成签到 ,获得积分10
10秒前
11秒前
Xiaopan完成签到,获得积分10
11秒前
xiaoming发布了新的文献求助200
12秒前
12秒前
QT完成签到,获得积分20
13秒前
朱华彪完成签到,获得积分10
13秒前
活在当下发布了新的文献求助10
13秒前
13秒前
haha发布了新的文献求助10
14秒前
aurora完成签到 ,获得积分10
15秒前
茉莉完成签到,获得积分10
15秒前
123完成签到,获得积分10
17秒前
17秒前
wwewew完成签到,获得积分10
18秒前
saying发布了新的文献求助10
18秒前
123123完成签到,获得积分10
18秒前
隐形曼青应助阿卡宁采纳,获得10
19秒前
负责紊完成签到,获得积分10
19秒前
善良的火发布了新的文献求助10
21秒前
haha完成签到,获得积分10
21秒前
23秒前
sugar完成签到,获得积分10
24秒前
活在当下完成签到,获得积分10
24秒前
26秒前
ssy发布了新的文献求助10
26秒前
小嘉贞完成签到,获得积分10
28秒前
鸡蛋黄完成签到,获得积分10
29秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048