心肌保护
医学
老化
心力衰竭
病理生理学
促炎细胞因子
心脏病学
缺血
内科学
风险因素
炎症
作者
Marisol Ruíz-Meana,Diana Bou-Teen,Péter Ferdinándy,Mariann Gyöngyösi,Maurizio Pesce,Cinzia Perrino,Rainer Schulz,Joost P.G. Sluijter,Carlo G. Tocchetti,Thomas Thum,Rosalinda Madonna
出处
期刊:Cardiovascular Research
[Oxford University Press]
日期:2020-05-08
卷期号:116 (11): 1835-1849
被引量:31
摘要
Abstract Advanced age is a major predisposing risk factor for the incidence of coronary syndromes and comorbid conditions which impact the heart response to cardioprotective interventions. Advanced age also significantly increases the risk of developing post-ischaemic adverse remodelling and heart failure after ischaemia/reperfusion (IR) injury. Some of the signalling pathways become defective or attenuated during ageing, whereas others with well-known detrimental consequences, such as glycoxidation or proinflammatory pathways, are exacerbated. The causative mechanisms responsible for all these changes are yet to be elucidated and are a matter of active research. Here, we review the current knowledge about the pathophysiology of cardiac ageing that eventually impacts on the increased susceptibility of cells to IR injury and can affect the efficiency of cardioprotective strategies.
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