曲古抑菌素A
伏立诺他
脂肪细胞
脂肪组织
表观遗传学
细胞分化
细胞生物学
化学
脂肪生成
组蛋白脱乙酰基酶
组蛋白
生物
生物化学
基因
作者
Xiao Wang,Zhimin Wang,Qing Wang,Hao Liang,Dongjun Liu
标识
DOI:10.1016/j.rvsc.2019.09.002
摘要
To explore the effect of epigenetic modification on the differentiation of goat adipose-derived stem cells in vitro, we used two common epigenetic modification inhibitors, trichostatin A and vorinostat, to treat cashmere goat adipose-derived stem cells and induce adipocyte differentiation. The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG) transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. We conclude that adipocyte differentiation is regulated dynamically by different histone modifications. The areas of acetylation and demethylation changed by trichostatin A and vorinostat are the basis for further research on the mechanism of PPARG promoter to regulate adipocytes differentiation and provide research theroies for using adipose-derived stem cells as donor to produce transgenic animals to improve meat quality improvement.
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