整合素
细胞生物学
功能(生物学)
化学
癌症研究
生物
受体
生物化学
作者
Bridie J. Goggins,Kyra Minahan,Simonne Sherwin,Wai Sinn Soh,Jennifer Pryor,Jessica Bruce,Gang Liu,Andrea Mathe,Darryl A. Knight,Jay C. Horvat,Marjorie M. Walker,Simon Keely
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2021-04-01
卷期号:320 (4): G420-G438
被引量:21
标识
DOI:10.1152/ajpgi.00192.2020
摘要
HIF-1 plays an important role in epithelial restitution, selectively inducing integrins α6 and α2 to promote migration and proliferation, respectively. HIF-stabilizing prolyl-hydroxylase inhibitors accelerate intestinal mucosal healing by inducing epithelial integrin expression.
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