化学
芳基
硅烷化
试剂
磺酸盐
苯
烷基
取代基
氟化物
药物化学
产量(工程)
有机化学
组合化学
催化作用
钠
无机化学
材料科学
冶金
作者
Bharat D. Dond,Shivaji N. Thore
标识
DOI:10.1016/j.tetlet.2020.151660
摘要
A one pot protocol for the transformation of aryl TBDMS ethers to corresponding benzene sulfonate esters using NFSI (N-flurobenzenesulfonimide)/KF is described. In situ generation of benzenesulfonyl fluoride directs chemoselective cleavage of aryl silyl ethers over alkyl silyl ethers. Electron withdrawing substituent’s on aryl ring provided better yield than donating groups. Protecting groups and sensitive functionalities are well tolerated in this methodology. Thus, commercially available inexpensive reagents, mild reaction conditions and step economy are the advantages of this method.
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