Recent advances in role of TAR DNA-binding protein 43 in pathogenesis of Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disease involving a variety of pathogenic factors. Studies have shown that TAR DNA-binding protein 43 (TDP-43) may cause AD pathological changes and induce cognitive dysfunction by increasing Aβ abnormal deposition, promoting Tau hyperphosphorylation, triggering mitochondrial dysfunction, and aggravating neuroinflammation. This paper reviews the important role of TDP-43 in the pathogenesis of AD. Key words: TAR DNA-binding protein 43; Alzheimer's disease; Cognitive dysfunction