Clinical efficacy and safety evaluation of urate oxidase

Hyperuricemia is a condition of abnormally high uric acid level in blood. Urate oxidase catalyzes enzymatic oxidation of uric acid to provide sustained reduction of plasma uric acid level. With the development of biotechnology, urate oxidase has been approved as a urate-lowering biological agent. Its efficacy and safety need further research and evaluation. This review summarizes the clinical application and efficacy and safety of urate oxidase as urate-lowering agent for hyperuricemia in recent years. The problems of application and future research directions are also discussed. Key words: Urate oxidase; Hyperuricemia; Treatment outcome; Safety