Maternal obesity and risk of cardiovascular diseases in offspring: a population-based cohort and sibling-controlled study

医学 后代 超重 危险系数 肥胖 人口 怀孕 体质指数 队列 儿科 比例危险模型 队列研究 产科 内科学 置信区间 环境卫生 生物 遗传学
作者
Neda Razaz,Eduardo Villamor,Giulia M. Muraca,Anna‐Karin Edstedt Bonamy,Sven Cnattingius
出处
期刊:The Lancet Diabetes & Endocrinology [Elsevier BV]
卷期号:8 (7): 572-581 被引量:64
标识
DOI:10.1016/s2213-8587(20)30151-0
摘要

Background Maternal overweight and obesity might increase risks of adiposity and cardiovascular and metabolic diseases in offspring. We examined associations between maternal overweight and obesity severity and risk of cardiovascular diseases in young offspring. Methods In this population-based cohort study, we used data from live singleton births recorded in the Swedish Medical Birth Register. We calculated maternal BMI in early pregnancy from self-reported height and weight measurements at the first prenatal visit. We used multivariable Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) and 95% CIs. We calculated the proportion of the associations mediated through known consequences of obesity that also predicted cardiovascular diseases and did family case-control analyses. Findings We identified 2 230 115 live singleton infants (without congenital malformations) in Sweden registered between Jan 1, 1992, and Dec 31, 2016. Overall, 1741 (0·08%) offspring were diagnosed with a cardiovascular disease between ages 1 and 25 years. Cardiovascular disease rates by maternal BMI categories were 0·57 per 10 000 child-years (BMI 18·5–24·9 kg/m2; normal weight), 0·61 per 10 000 child-years (25·0–29·9 kg/m2; overweight), 0·67 per 10 000 child-years (30·0–34·9 kg/m2; obesity grade I), 1·02 per 10 000 child-years (35·0–39·9 kg/m2; obesity grade II), and 1·38 per 10 000 child-years (≥40·0 kg/m2; obesity grade III). Compared with offspring of mothers with normal BMI, HRs of cardiovascular diseases were 1·10 (95% CI 0·97–1·25) for overweight, 1·16 (0·95–1·43) for obesity grade I, 1·84 (1·36–2·49) for obesity grade II, and 2·51 (1·60–3·92) for obesity grade III. Risks of cerebrovascular diseases increased with maternal obesity severity and were partly mediated through asphyxia-related neonatal complications. The sibling-cohort analysis also indicated a positive trend between maternal BMI and cardiovascular disease rates. Interpretations Our findings indicate that maternal obesity might be a risk factor for cardiovascular diseases in childhood and early adulthood. These results need to be replicated and possible underlying mechanisms identified. Funding Swedish Research Council for Health, Working Life and Welfare.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
sunyanghu369发布了新的文献求助30
刚刚
hdc12138完成签到,获得积分10
1秒前
飞龙在天完成签到,获得积分0
1秒前
狄淇儿完成签到 ,获得积分10
1秒前
吨吨完成签到,获得积分10
2秒前
小芒果完成签到,获得积分0
6秒前
7秒前
杰克李李完成签到,获得积分10
8秒前
pakiorder完成签到,获得积分20
10秒前
无心的雅霜完成签到,获得积分10
10秒前
1122完成签到,获得积分10
11秒前
王磊完成签到,获得积分10
11秒前
顺心醉蝶完成签到 ,获得积分10
11秒前
量子星尘发布了新的文献求助10
11秒前
zhao完成签到 ,获得积分10
12秒前
yuncong323发布了新的文献求助10
12秒前
gfasdjsjdsjd发布了新的文献求助30
14秒前
pan完成签到,获得积分10
14秒前
15秒前
16秒前
魔幻的妖丽完成签到 ,获得积分10
18秒前
王小凡完成签到 ,获得积分10
18秒前
19秒前
开心薯片发布了新的文献求助10
20秒前
ZXW完成签到,获得积分10
21秒前
莉莉发布了新的文献求助10
21秒前
眼睛大的擎苍完成签到,获得积分10
23秒前
xr完成签到,获得积分10
24秒前
ZORO完成签到,获得积分10
24秒前
25秒前
临时演员完成签到,获得积分10
26秒前
ABCDE完成签到,获得积分10
26秒前
taotao完成签到,获得积分10
26秒前
ED应助莉莉采纳,获得10
27秒前
ED应助莉莉采纳,获得10
27秒前
扣扣登陆完成签到 ,获得积分10
27秒前
28秒前
白日焰火完成签到 ,获得积分10
28秒前
29秒前
29秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022