Maternal obesity and risk of cardiovascular diseases in offspring: a population-based cohort and sibling-controlled study

医学 后代 超重 危险系数 肥胖 人口 怀孕 体质指数 队列 儿科 比例危险模型 队列研究 产科 内科学 置信区间 环境卫生 生物 遗传学
作者
Neda Razaz,Eduardo Villamor,Giulia M. Muraca,Anna‐Karin Edstedt Bonamy,Sven Cnattingius
出处
期刊:The Lancet Diabetes & Endocrinology [Elsevier BV]
卷期号:8 (7): 572-581 被引量:64
标识
DOI:10.1016/s2213-8587(20)30151-0
摘要

Background Maternal overweight and obesity might increase risks of adiposity and cardiovascular and metabolic diseases in offspring. We examined associations between maternal overweight and obesity severity and risk of cardiovascular diseases in young offspring. Methods In this population-based cohort study, we used data from live singleton births recorded in the Swedish Medical Birth Register. We calculated maternal BMI in early pregnancy from self-reported height and weight measurements at the first prenatal visit. We used multivariable Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) and 95% CIs. We calculated the proportion of the associations mediated through known consequences of obesity that also predicted cardiovascular diseases and did family case-control analyses. Findings We identified 2 230 115 live singleton infants (without congenital malformations) in Sweden registered between Jan 1, 1992, and Dec 31, 2016. Overall, 1741 (0·08%) offspring were diagnosed with a cardiovascular disease between ages 1 and 25 years. Cardiovascular disease rates by maternal BMI categories were 0·57 per 10 000 child-years (BMI 18·5–24·9 kg/m2; normal weight), 0·61 per 10 000 child-years (25·0–29·9 kg/m2; overweight), 0·67 per 10 000 child-years (30·0–34·9 kg/m2; obesity grade I), 1·02 per 10 000 child-years (35·0–39·9 kg/m2; obesity grade II), and 1·38 per 10 000 child-years (≥40·0 kg/m2; obesity grade III). Compared with offspring of mothers with normal BMI, HRs of cardiovascular diseases were 1·10 (95% CI 0·97–1·25) for overweight, 1·16 (0·95–1·43) for obesity grade I, 1·84 (1·36–2·49) for obesity grade II, and 2·51 (1·60–3·92) for obesity grade III. Risks of cerebrovascular diseases increased with maternal obesity severity and were partly mediated through asphyxia-related neonatal complications. The sibling-cohort analysis also indicated a positive trend between maternal BMI and cardiovascular disease rates. Interpretations Our findings indicate that maternal obesity might be a risk factor for cardiovascular diseases in childhood and early adulthood. These results need to be replicated and possible underlying mechanisms identified. Funding Swedish Research Council for Health, Working Life and Welfare.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
bkagyin应助夏梦园采纳,获得10
刚刚
如如要动发布了新的文献求助200
刚刚
1秒前
FFFFFFG完成签到,获得积分10
2秒前
2秒前
3秒前
4秒前
sigla发布了新的文献求助10
4秒前
wss完成签到,获得积分10
4秒前
跳跃忆灵完成签到,获得积分10
4秒前
左凝阳发布了新的文献求助10
4秒前
风中幻梦发布了新的文献求助10
5秒前
5秒前
5秒前
SYLH应助飞云采纳,获得10
5秒前
研友_VZG7GZ应助疗效采纳,获得10
6秒前
6秒前
6秒前
一朵梅花完成签到,获得积分10
8秒前
9秒前
monoklatt发布了新的文献求助30
9秒前
wss发布了新的文献求助10
10秒前
脑洞疼应助大剑日太刀采纳,获得10
10秒前
Synan完成签到,获得积分10
11秒前
李健的小迷弟应助orange9采纳,获得10
11秒前
tx完成签到,获得积分20
12秒前
艾小晗发布了新的文献求助20
12秒前
asbefore完成签到,获得积分10
12秒前
lzc完成签到,获得积分10
12秒前
寒冷兔子发布了新的文献求助10
12秒前
Imwang完成签到,获得积分10
13秒前
13秒前
蓝天白云完成签到,获得积分10
13秒前
希光光完成签到,获得积分10
14秒前
Li发布了新的文献求助10
14秒前
CipherSage应助圆圆采纳,获得10
14秒前
左凝阳完成签到,获得积分20
15秒前
15秒前
kecheng应助wangsiyuan采纳,获得10
15秒前
沫沫发布了新的文献求助10
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970120
求助须知:如何正确求助?哪些是违规求助? 3514810
关于积分的说明 11176124
捐赠科研通 3250136
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875647
科研通“疑难数据库(出版商)”最低求助积分说明 804964