转鼓
光催化
溴化物
催化作用
乙烯基
光化学
可见光谱
反应性(心理学)
光催化
化学
还原消去
激进的
组合化学
有机化学
二苯甲酮
亲核细胞
病理
替代医学
物理
医学
光电子学
作者
Zhongzhen Wang,Qiong Liu,Xiaochen Ji,Guo‐Jun Deng,Huawen Huang
标识
DOI:10.1021/acscatal.9b04411
摘要
Radical addition is a robust tool for bond formation. While ketyl radical reactivity of aldehydes by photoredox has been well-established, herein, we have now revealed a pathway for umpolung addition of aldehydes with or without external reductant. Hence, the reductive alkylations and challenging benzylations of nitrogen heteroarenes (i.e., Minisci reactions) are enabled by the bromide-promoted visible light-mediated photocatalysis. The present protocol offers a mild, viable method for late-stage alkylations and transition-metal-free benzylations of biologically active nitrogen-heteroarene molecules. Mechanistic studies are indicative of a bromide-initiated acyl radical mechanism in the absence of external reductant.
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