阿芬太尼
舒芬太尼
芬太尼
血液蛋白质类
药理学
血浆蛋白结合
化学
麻醉
血浆
医学
内科学
作者
W. Meuldermans,R Hurkmans,J Heykants
出处
期刊:PubMed
日期:1982-05-01
卷期号:257 (1): 4-19
被引量:158
摘要
The in vitro plasma protein binding and distribution in blood of fentanyl and three analogues were studied in rats, dogs and healthy volunteers. In human plasma, 84.4% of fentanyl was bound, 92.5% of sufentanil, 92.1% of alfentanil and 93.6% of lofentanil. Plasma protein binding of the four analgesics was independent of their concentration over the whole therapeutic range. Plasma protein binding of alfentanil was much less pH dependent than that of the three other analgesics. Attention was drawn to the possible contribution of the "acute phase' protein alpha 1-acid glycoprotein (alpha 1-AGP), of lipoproteins and of blood cells to the binding of fentanyl and its analogues in blood.
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