Infectious mononucleosis ("mono") is an infection that causes sore throat, fever, swollen glands, and tiredness or fatigue. Causes of Infectious MononucleosisInfectious mononucleosis is transmitted by exposure to saliva, so it can be spread by kissing, by sharing glasses or cutlery, and by droplets spread by coughing.Mono is usually caused by the Epstein-Barr virus.It most often affects children, teenagers, and young adults.Other diseases that cause similar symptoms include infection with other viruses that cause sore throat, streptococcal bacteria ("strep throat"), or cytomegalovirus.