化学
内吞循环
纳米载体
细胞内
胶束
光热治疗
共轭体系
生物物理学
光敏剂
内化
胞浆
质子化
光热效应
光化学
光动力疗法
共聚物
内体
药物输送
纳米技术
生物化学
有机化学
内吞作用
水溶液
聚合物
酶
离子
材料科学
细胞
生物
作者
Guhuan Liu,Jinming Hu,Guoying Zhang,Shiyong Liu
摘要
Spatiotemporal switching of respective phototherapy modes at the cellular level with minimum side effects and high therapeutic efficacy is a major challenge for cancer phototherapy. Herein we demonstrate how to address this issue by employing photosensitizer-conjugated pH-responsive block copolymers in combination with intracellular endocytic pH gradients. At neutral pH corresponding to extracellular and cytosol milieu, the copolymers self-assemble into micelles with prominently quenched fluorescence emission and low 1O2 generation capability, favoring a highly efficient photothermal module. Under mildly acidic pH associated with endolysosomes, protonation-triggered micelle-to-unimer transition results in recovered emission and enhanced photodynamic 1O2 efficiency, which synergistically actuates release of encapsulated drugs, endosomal escape, and photochemical internalization processes.
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