Changes of brain default-mode network connectivity in patients with transient ischemic attack

Objective To investigate the changes of brain default-mode network(DMN) connectivity in patients with transient ischemic attack(TIA).Methods Sixteen interictal TIA patients and 16 normal controls were underwent with functional MR scan.The regions of interest(ROI) were set on the cingulate/precuneus and ventral anterior cingulate/medial prefrontal,and the average time signal in which were extraction.The connectivity of brain regions connected with ROI was analyzed.Results Compared with the normal control group,the functional connectivity in TIA group was reduced on left anterior cingulate gyrus and hippocampus,right anterior frontal gyrus,insular lobe,precuneus and inferior parietal lobule;and which enhanced on right cerebellum,thalamus and caudate nucleus.Conclusions The brain DMN is abnormal in TIA patients.The connectivity of part brain region reduced.The connectivity increased on thalamus and cerebellum may be the compensation of brain function or protective response.