脂肪性肝炎
脂肪肝
纤维化
脂肪变性
肝硬化
肝细胞癌
医学
肝癌
四氯化碳
肝病
癌症研究
病理
内科学
生物
疾病
化学
有机化学
作者
Takuma Tsuchida,Youngmin A. Lee,Naoto Fujiwara,Maria D. Ybanez,Brittany N. Allen,Sebastião N. Martins-Filho,Maria Isabel Fiel,Nicolas Goossens,Hsin-I Chou,Yujin Hoshida,Scott L. Friedman
标识
DOI:10.1016/j.jhep.2018.03.011
摘要
A carefully characterized model has been developed in mice that recapitulates the progressive stages of human fatty liver disease, from simple steatosis, to inflammation, fibrosis and cancer. The functional pathways of gene expression and immune abnormalities in this model closely resemble human disease. The ease and reproducibility of this model make it ideal to study disease pathogenesis and test new treatments.
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