医学
置信区间
入射(几何)
混淆
随机对照试验
铅笔(光学)
脊髓麻醉
相对风险
荟萃分析
外科
子群分析
麻醉
内科学
光学
物理
工程类
机械工程
作者
Andrés Zorrilla-Vaca,Vineesh Mathur,Christopher L. Wu,Michael C. Grant
出处
期刊:Regional Anesthesia and Pain Medicine
[BMJ]
日期:2018-04-01
卷期号:: 1-1
被引量:24
标识
DOI:10.1097/aap.0000000000000775
摘要
Background and Objectives
Potentially broadened indications for spinal anesthesia require increased understanding of the risk factors and prevention measures associated with postdural puncture headache (PDPH). This review is designed to examine the association between spinal needle characteristics and incidence of PDPH. Methods
Meta-analysis and metaregression was performed on randomized controlled trials to determine the effect of needle design and gauge on the incidence of PDPH after controlling for patient confounders such as age, sex, and year of publication. Results
Fifty-seven randomized controlled trials (n = 16416) were included in our analysis, of which 32 compared pencil-point design with cutting-needle design and 25 compared individual gauges of similar design. Pencil-point design was associated with a statistically significant reduction in incidence of PDPH (risk ratio, 0.41; 95% confidence interval, 0.31–0.54; P < 0.001; I2 = 29%) compared with cutting needles among studies that assessed both design types. Subgroup analysis among obstetric and nonobstetric procedures yielded similar results. After adjustment for significant covariates, metaregression analysis among all 57 included trials revealed a significant correlation between needle gauge and rate of PDPH among cutting needles (slope = −2.65, P < 0.001), but not pencil-point needles (slope = −0.01, P = 0.819). Conclusions
Pencil-point needles are associated with significantly lower incidence of PDPH compared with the cutting-needle design. Whereas a significant relationship was noted between needle gauge and PDPH for cutting-needle design, a similar association was not shown for pencil-point needles. Providers may consider selection of larger-caliber pencil-point needle to maximize technical proficiency without expensing increased rates of PDPH.
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