突变
赫拉
化学
聚酮
青霉属
生物
生物合成
MTT法
立体化学
生物化学
细胞毒性
突变体
基因
植物
体外
作者
Ming-Wen Xia,Yu Yang,Rui Xu,Chengwei Li,Cheng‐Bin Cui
标识
DOI:10.1080/14786419.2018.1434644
摘要
A new polyketide, purpurogenic acid (1), and two known polyketides, (-)-mitorubrin (2) and (-)-mitorubrinol (3), were isolated from a fungal mutant derived from the diethyl sulphate (DES) mutagenesis of marine-derived Penicillium purpurogenum G59. The planar structure of new 1 was elucidated by spectroscopic methods and the absolute configuration was assigned on the basis of [α]D and CD data. In our preliminary MTT assay, 1 inhibited human cancer K562, HL-60, HeLa and BGC-823 cells with the inhibition rates of 52.7, 78.8, 38.4 and 35.3% at the 100 μg/mL, respectively.
科研通智能强力驱动
Strongly Powered by AbleSci AI