Short latency intracortical inhibition in the angular gyrus characterized by paired-pulse TMS and EEG co-registration

Event Abstract Back to Event Short latency intracortical inhibition in the angular gyrus characterized by paired-pulse TMS and EEG co-registration Dominika Sulcova1*, Adriana Salatino1 and André Mouraux1 1 Université Catholique de Louvain, Institute of Neuroscience, Belgium Short-latency intracortical inhibition (SICI) represents the manifestation of local cortico-cortical inhibitory transmission mediated by GABAA receptors. It is commonly measured using motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS), restricting the focus to the primary motor cortex. The introduction of TMS-compatible EEG allows to measure TMS-evoked brain potentials (TEPs) from non-motor areas. Our aim was to characterize SICI in one of these areas, the angular gyrus (AG), using a combined TMS-EEG protocol. This way, we aim to describe with more precision the function of local GABAergic circuits. 10 healthy young volunteers participated in six blocks of TMS stimulation with multichannel EEG co-registration divided into two separate sessions. Both single and paired-pulse TMS were applied over the left AG. In the paired-pulse trials, two different intensities of both testing (at 60% and at 80% of resting Motor Threshold-rMT) and conditioning (at 100% and at 120% of rMT) stimuli were examined with the inter-stimulus interval of 2.5 ms. Each condition was tested 80 times while different stimuli were delivered in randomized order. In addition, the SICI in the left primary motor cortex was measured using MEPs recorded from the contralateral hand in a separate block. Our preliminary results suggest that it is possible to use TEPs to study SICI in non-motor areas such as the AG, in terms of changes in amplitude of short latency deflections in TEPs. The paired-pulse TMS protocol could therefore serve as a new non-invasive tool for assessment of GABAA receptor-mediated neurotransmission in non-motor areas. Keywords: TMS, TMS-Evoked EEG potential, EEG & ERP, noninvasive brain stimulation, GABA, angular gyrus (AG), SICI = short-interval intracortical inhibition Conference: Belgian Brain Congress 2018 — Belgian Brain Council, LIEGE, Belgium, 19 Oct - 19 Oct, 2018. Presentation Type: e-posters Topic: NOVEL STRATEGIES FOR NEUROLOGICAL AND MENTAL DISORDERS: SCIENTIFIC BASIS AND VALUE FOR PATIENT-CENTERED CARE Citation: Sulcova D, Salatino A and Mouraux A (2019). Short latency intracortical inhibition in the angular gyrus characterized by paired-pulse TMS and EEG co-registration. Front. Neurosci. Conference Abstract: Belgian Brain Congress 2018 — Belgian Brain Council. doi: 10.3389/conf.fnins.2018.95.00078 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Aug 2018; Published Online: 17 Jan 2019. * Correspondence: Miss. Dominika Sulcova, Université Catholique de Louvain, Institute of Neuroscience, Louvain-la-Neuve, Belgium, dominika.sulcova@uclouvain.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Dominika Sulcova Adriana Salatino André Mouraux Google Dominika Sulcova Adriana Salatino André Mouraux Google Scholar Dominika Sulcova Adriana Salatino André Mouraux PubMed Dominika Sulcova Adriana Salatino André Mouraux Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.