化学
氮丙啶
糖复合物
加合物
组合化学
分子内力
叠氮化物
基础(拓扑)
基质(水族馆)
立体化学
有机化学
生物化学
戒指(化学)
海洋学
地质学
数学分析
数学
作者
Rekha Sangwan,Atul Dubey,Gurudayal Prajapati,Ravi Sankar Ampapathi⧧,Pintu Kumar Mandal
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-04-04
卷期号:21 (8): 2859-2862
被引量:8
标识
DOI:10.1021/acs.orglett.9b00862
摘要
The base-promoted intramolecular cyclization of Ugi-azide adduct has been demonstrated for the synthesis of highly substituted aziridinyl glycoconjugates in one pot. The reactions are scalable and efficient and have an operationally simple broad substrate scope. To gain insight into the mechanism of aziridine formation, DFT and control experiments show that the cyclization of the aziridine glycoconjugate pathway was preferred, as it proceeds with a low activation energy barrier (0.57 kcal mol–1), which supports our experimental observation.
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