光热治疗
材料科学
三阴性乳腺癌
细胞凋亡
碳纳米管
体内
纳米技术
癌症研究
表面改性
癌症
癌细胞
活性氧
光热效应
生物物理学
乳腺癌
细胞生物学
生物
化学
生物化学
物理化学
生物技术
遗传学
作者
Chaoming Mei,Ni Wang,Xueqiong Zhu,Ka‐Hing Wong,Tianfeng Chen
标识
DOI:10.1002/adfm.201805225
摘要
Abstract Owing to the highly malignant and invasive innate character of triple‐negative breast cancers (TNBCs), it is easy to relapse after chemotherapy; thus, there are still no effective and specific targeted therapies. In this study, a carbon nanotube (CNT)‐based nanosystem Se@CNTs with surface charge flipping and targeted ability is rationally designed and successfully synthesized for precise chemo‐photothermal synergistic therapy of TNBCs. The acid‐labile β‐carboxylic acid group is used to reversibly functionalize the amine groups, thus forming charge‐reversal nanoparticles to enhance the bioresponsive cellular uptake. The internalized Se@CNTs combined with laser irradiation induces reactive oxygen species (ROS) overproduction, which activates apoptosis‐related proteins to trigger cancer cell apoptosis synergistically. Meanwhile, Se@CNTs also suppresses the invasion and migration of TNBC cells by regulating the related signaling pathways. Importantly, in combination with laser irradiation, Se@CNTs effectively inhibits the tumor growth, as demonstrated by the high tumor ablation activity in vivo through chemo‐phototherapy, but shows no significant histological change in the main organs. Taken together, this study provides a strategy for rational design of next‐generation nanomedicines for precise chemo‐photothermal synergistic therapy of malignant TNBCs.
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