Drug Delivery: pH and Reactive Oxygen Species‐Sequential Responsive Nano‐in‐Micro Composite for Targeted Therapy of Inflammatory Bowel Disease (Adv. Funct. Mater. 50/2018)

In article number 1806175, Nadia Passerini, Wei Li, Hélder A. Santos, and co-workers report a nano-in-micro composite for targeted therapy of inflammatory bowel disease via oral administration. The composite responds sequentially to pH and reactive oxygen species. The drug permeation through intestinal epithelium is also limited, providing a promising approach to limit unspecific absorption and systemic side effects.