Recent advances in flavonoid-grafted polysaccharides: Synthesis, structural characterization, bioactivities and potential applications

Plant derived flavonoids have been demonstrated to possess many valuable biological functions. In recent years, flavonoids have been successfully conjugated with polysaccharides through different graft copolymerization methods including chemical coupling, enzyme catalysis, free radical mediated grafting, and acid catalyzed condensation reactions. The successful grafting of flavonoids onto polysaccharides can be confirmed by several instrumental methods. The conjugation of flavonoids can significantly improve the antioxidant, antimicrobial, antitumor, hepatoprotective and enzyme inhibition properties of polysaccharides. Moreover, the applications of polysaccharides in food and pharmaceutical industries can be greatly broadened by grafting with flavonoids. Flavonoid-grafted polysaccharides can be developed as films for active packaging, hydrogels for controlled drug release, micelles for oral drug delivery, and emulsions for nutraceutical delivery. In general, the bioactivities and applications of conjugates are closely related to the type of flavonoid grafted, the grafting method used as well as the grafting efficiency. Recent advances in the synthesis, structural characterization, bioactivities and potential applications of flavonoid-grafted polysaccharides are summarized in this review.