熊果酸
结直肠癌
细胞毒性T细胞
乳腺癌
体内
癌症
三萜
医学
传统医学
体外
癌症研究
药理学
化学
生物
内科学
生物化学
植物
病理
替代医学
生物技术
作者
Eric Wei Chiang Chan,Chu Yong Soon,Joash Ban Lee Tan,Siu Kuin Wong,Yew Woh Hui
标识
DOI:10.1016/j.joim.2019.03.003
摘要
Ursolic acid (UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer (BC) and colorectal cancer (CRC) that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways. There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the -OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives. Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed.
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