Platelet Glycobiology and the Control of Platelet Function and Lifespan

Abstract In response to hemorrhage, circulating platelets roll on exposed subendothelium, adhere, and form aggregates to seal a vascular leak. These processes involve platelet receptors, including the von Willebrand factor receptor complex, glycoprotein VI, selectins, and integrins. The role of glycans in these processes is currently rapidly emerging, although past literature clearly shows a role for glycans in platelet function. Platelet aging in vivo and in vitro, and platelets exposed to temperatures