免疫疗法
医学
免疫学
免疫系统
慢性肝炎
获得性免疫系统
病毒
乙型肝炎病毒
免疫
免疫功能障碍
乙型肝炎
病毒学
作者
Adam J. Gehring,Ulrike Protzer
标识
DOI:10.1053/j.gastro.2018.10.032
摘要
Fewer than 1% of chronic hepatitis B virus infections per year are cured with antiviral treatment. This creates a need for long-term treatment, which poses challenges for patients and health systems. Because cure is accompanied by recovery of antiviral immunity, a combination of direct-acting antiviral agents and immunotherapy are likely to be required. Extensive efforts have been made to identify determinants of the failed immune response to hepatitis B virus in patients with chronic infection. We review mechanisms of immune dysfunction in patients with chronic hepatitis B virus infection, immunotherapy strategies in development, and the challenges associated with successful implementation of immunotherapy.
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