细菌外膜
细菌
鲍曼不动杆菌
革兰氏阴性菌
铜绿假单胞菌
抗菌剂
微生物学
脂多糖
肺炎克雷伯菌
革兰氏阳性菌
抗生素耐药性
大肠杆菌
生物
抗生素
生物化学
内分泌学
基因
遗传学
作者
Umji Choi,Chang‐Ro Lee
出处
期刊:Journal of Microbiology and Biotechnology
[Springer Science+Business Media]
日期:2019-01-28
卷期号:29 (1): 1-10
被引量:72
标识
DOI:10.4014/jmb.1804.03051
摘要
Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, pose a serious threat to public health worldwide, due to high rates of antibiotic resistance and the lack of development of novel antimicrobial agents targeting Gram-negative bacteria. The outer membrane (OM) of Gram-negative bacteria is a unique architecture that acts as a potent permeability barrier against toxic molecules, such as antibiotics. The OM is composed of phospholipids, lipopolysaccharide (LPS), outer membrane β-barrel proteins (OMP), and lipoproteins. These components are synthesized in the cytoplasm or in the inner membrane, and are then selectively transported to the OM by the specific transport machines, including the Lol, BAM, and Lpt pathways. In this review, we summarize recent studies on the assembly systems of OM components and analyze studies for the development of inhibitors that target these systems. These analyses show that OM assembly machines have the potential to be a novel attractive drug target of Gram-negative bacteria.
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