细菌外膜
细菌
鲍曼不动杆菌
革兰氏阴性菌
铜绿假单胞菌
抗菌剂
微生物学
脂多糖
肺炎克雷伯菌
抗菌肽
革兰氏阳性菌
细菌细胞结构
大肠杆菌
膜
多粘菌素
多粘菌素B
流出
致病菌
生物
单元格信封
肽聚糖
金黄色葡萄球菌
周质间隙
抗生素
抗菌活性
生物化学
遗传学
基因
内分泌学
作者
Umji Choi,Chang-Ro Lee
出处
期刊:Journal of Microbiology and Biotechnology
[Journal of Microbiology and Biotechnology]
日期:2019-01-28
卷期号:29 (1): 1-10
被引量:52
标识
DOI:10.4014/jmb.1804.03051
摘要
Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, pose a serious threat to public health worldwide, due to high rates of antibiotic resistance and the lack of development of novel antimicrobial agents targeting Gram-negative bacteria. The outer membrane (OM) of Gram-negative bacteria is a unique architecture that acts as a potent permeability barrier against toxic molecules, such as antibiotics. The OM is composed of phospholipids, lipopolysaccharide (LPS), outer membrane β-barrel proteins (OMP), and lipoproteins. These components are synthesized in the cytoplasm or in the inner membrane, and are then selectively transported to the OM by the specific transport machines, including the Lol, BAM, and Lpt pathways. In this review, we summarize recent studies on the assembly systems of OM components and analyze studies for the development of inhibitors that target these systems. These analyses show that OM assembly machines have the potential to be a novel attractive drug target of Gram-negative bacteria.
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